Würzburg Childcare Study during the COVID-19 pandemic - A study into the acceptance of different screening measures for the detection of infections with the novel coronavirus (SARS-CoV-2) in child daycare centres in Würzburg

Aims: Feasibility study of different screening measures for the surveillance of SARS-CoV-2 infections of daycare children and staff; possible predictors for the acceptance will be determined; psychosocial implications of the surveillance for several months for daycare children, parents, and staff will be evaluated; costs of the surveillance measures will be estimated; seroprevalence data and the number of SARS-CoV-2 infections of daycare children and staff in Würzburg will be collected.

Methods: Surveillance concepts: monitoring of daycare children and staff via nasal swaps once or twice a week, or via collection of saliva samples twice a week; alternatively monitoring of daycare children, staff and their household members due to cold symptoms. All 4 monitoring concepts will be running for 12 weeks.

Additionally, seroprevalence will be determined and parents/guardians, daycare staff and children will be interviewed at defined time points for the collection of sociodemographic data and psychosocial implications; symptomatic household members will be inquired about symptoms of acute respiratory infections and their exposure to SARS-CoV-2.

Laboratory diagnostics: detection of SARS-CoV-2 infections via PCR from nasal swaps or saliva sample (daycare children and staff), or from throat swaps (household members); detection of antibodies (point-of-care- test from finger-prick test, or ELISA from serum).

Study Overview

Study name	Würzburg Childcare Study during the COVID-19 pandemic - A study into the acceptance of different screening measures for the detection of infections with the novel coronavirus (SARS-CoV-2) in child daycare centres in Würzburg
Project	Wü-KiTa-CoV
Sources of Monetary or Material Support	Federal Ministry of Education and Research (BMBF)
Region(s)	Germany
Location(s)	Würzburg
Primary outcome	Assessment of acceptance rates of various surveillance measures for the detection of SARS-CoV-2 infections in daycare children, staff, and their household members; detection of SARS-CoV-2 infections via PCR from nasal swaps or saliva samples from daycare children and staff; for household members from throat swaps;
Secondary outcome	Collection of basic data of SARS-CoV-2 seroprevalence and the number of SARS-CoV-2 infections in daycare children and staff in Würzburg (point-of-care-test via finger-prick testing or ELISA from serum); rate of positive serological tests and positive PCR tests.
Diagnostic test(s) used	PANBIO™ COVID-19 Ag RAPID TEST DEVICE , Abbott , Multiplex Serology
Antibody class(es)	IgG, IgM
Study population N	1000
Principal Investigator	Oliver Kurzai and Johannes Liese , University Würzburg , wuekitacov@uni-wuerzburg.de
Team members	Oliver Kurzai, Principal Investigator, University Würzburg Johannes Liese, Principal Investigator, University Würzburg Johannes Forster, Study Coordinator, University Würzburg Andrea Streng, Study Coordinator, University Würzburg
WWW	https://www.med.uni-wuerzburg.de/wuekitacov/startseite/
Period	2020-10
Study start	2020-10

Study metadata

{
   "abbreviation": "Wü-KiTa-CoV",
   "draft": false,
   "iscjklanguage": false,
   "lastmod": "2020-12-16T08:55:07+01:00",
   "logo_url": "/img/uploads/wukitacov.jpg",
   "project_url": "https://www.med.uni-wuerzburg.de/wuekitacov/startseite/",
   "recruitment": {
     "country": [
       "Germany"
     ],
     "group": "children",
     "location": [
       {
         "latitude": 49.783333,
         "longitude": 9.933333,
         "place_name": "Würzburg"
       }
     ],
     "type": "feasibility study"
   },
   "study_dates": {
     "sample_end": "",
     "sample_start": "2020-10",
     "study_first_results": "",
     "study_start": "2020-10"
   },
   "study_info": {
     "diagnostic_test": [
       {
         "antibody_classes": [
           "IgG",
           "IgM"
         ],
         "company": "Abbott",
         "product": "PANBIO™ COVID-19 Ag RAPID TEST DEVICE",
         "type": "Multiplex Serology"
       }
     ],
     "funding_sources": "Federal Ministry of Education and Research (BMBF)",
     "primary_outcomes": "Assessment of acceptance rates of various surveillance measures for the detection of SARS-CoV-2 infections in daycare children, staff, and their household members; detection of SARS-CoV-2 infections via PCR from nasal swaps or saliva samples from daycare children and staff; for household members from throat swaps;",
     "secondary_outcomes": "Collection of basic data of SARS-CoV-2 seroprevalence and the number of SARS-CoV-2 infections in daycare children and staff in Würzburg (point-of-care-test via finger-prick testing or ELISA from serum); rate of positive serological tests and positive PCR tests.",
     "tested_antibody_classes": [
       "IgG",
       "IgM"
     ]
   },
   "study_numbers": {
     "study_population": 1000
   },
   "study_pi": {
     "email": "wuekitacov@uni-wuerzburg.de",
     "institution": "University Würzburg",
     "name": "Oliver Kurzai and Johannes Liese",
     "role": "Professor"
   },
   "team": [
     {
       "institution": "University Würzburg",
       "name": "Oliver Kurzai",
       "position": "Head of Department for Hygiene and Microbiology",
       "role": "Principal Investigator",
       "title": "Prof. Dr. med."
     },
     {
       "institution": "University Würzburg",
       "name": "Johannes Liese",
       "role": "Principal Investigator",
       "title": "Prof. Dr. med."
     },
     {
       "institution": "University Würzburg",
       "name": "Johannes Forster",
       "position": "Researcher",
       "role": "Study Coordinator"
     },
     {
       "institution": "University Würzburg",
       "name": "Andrea Streng",
       "position": "Researcher",
       "role": "Study Coordinator"
     }
   ],
   "title": "Würzburg Childcare Study during the COVID-19 pandemic - A study into the acceptance of different screening measures for the detection of infections with the novel coronavirus (SARS-CoV-2) in child daycare centres in Würzburg"
 }