Some of the COVID-19 cases have been found to have no or only mild symptoms. Those asymptomatic cases can become a source of transmission of the virus, especially for vulnerable groups such as older adults or people with comorbidities. Due to that, it is important to estimate the real burden of the disease and to go beyond symptomatic cases.
Study population
We propose a cross-sectional study to estimate SARS-CoV-2 seroprevalence in children and adolescents between 6 and 18 years old attending educational institutions at the city of Bogotá, Colombia. It also seeks to explore factors associated with SARS-CoV-2 seropositivity and symptomatology.
Methodology
We designed a specific questionnaire for COVID-19 to collect information related to symptoms, exposure, and associated factors. Moreover, we are going to collect venous blood samples and to study the presence of antibodies to SARS-CoV-2 using a differential multiple serology. The diagnostic test is based on luminescence (Luminex) that would allow the detection of specific humoral immune responses in serum samples.
Analysis
We propose a descriptive analysis of the data according sex, age and age groups, exposure, and self-reported symptoms. We are going to calculate the proportion of seropositive individuals, and the proportion of symptomatic and asymptomatic cases. We will perform univariate, bivariate, stratified and multivariate analysis, and will calculate measures of association.
Insights
We consider that our results will have a significant impact on the knowledge of the epidemiology of SARS-CoV-2 in Colombia. It will provide information on the incidence of the virus in children and adolescents and will provide information on risk and protective factors.
Study Overview
| Study name | Seroepidemiologic study on SARS CoV2 infection in scholar children in Bogotá, Colombia |
| Project | SESCiB |
| Sources of Monetary or Material Support | Helmholtz Centre for Infection Research (HZI) |
| Region(s) | Colombia |
| Location(s) | Bogotá |
| Primary outcome | (1) Seroprevalence of SARS-Cov-2, (2) Asymptomatic infection ratio, (3) Associated clinical, socioeconomic, and demographic factors. |
| Research Question | (1) Estimate the proportion of scholar children and adolescents with identified IgG and IgM antibodies against SARS-CoV-2. (2) Determine the proportion of asymptomatic or subclinical infections in SARS-CoV-2 positive individuals. (3) Explore social, demographic, economic, and clinical factors that may be potentially associated with seropositivity to SARS-CoV-2 in children and adolescents. |
| Diagnostic test(s) used |
|
| Antibody class(es) | IgG, IgA |
| Study population N | 1000 |
| Total population in the area | 1200000 |
| Principal Investigator | Gérard Krause and Fernando Pio De La Hoz Restrepo , Helmholtz (HZI) and Universidad Nacional de Colombia , serohub@helmholtz-hzi.de |
| Team members |
|
| Period | 2020-09 till 2021-04 |
| Study start | 2020-06 |
| First results expected | 2020-11 |
Study metadata
{
"abbreviation": "SESCiB",
"draft": false,
"iscjklanguage": false,
"lastmod": "2020-07-22T16:10:00+02:00",
"recruitment": {
"country": [
"Colombia"
],
"group": "children",
"location": [
{
"latitude": 4.624335,
"longitude": -74.063644,
"place_name": "Bogotá"
}
],
"type": "randomised individual invited voluntary"
},
"study_coord": {
"email": "serohub@helmholtz-hzi.de",
"institution": "Helmholtz (HZI)",
"name": "Nathalie Verónica Fernández Villalobos",
"role": "PhD student"
},
"study_dates": {
"sample_end": "2021-04",
"sample_start": "2020-09",
"study_first_results": "2020-11",
"study_start": "2020-06"
},
"study_info": {
"diagnostic_test": [
{
"antibody_classes": [
"IgM",
"IgG"
],
"company": "Luminex Corp.",
"product": "Point-of-care test",
"type": ""
}
],
"funding_sources": "Helmholtz Centre for Infection Research (HZI)",
"primary_outcomes": "(1) Seroprevalence of SARS-Cov-2, (2) Asymptomatic infection ratio, (3) Associated clinical, socioeconomic, and demographic factors.",
"research_question": "(1) Estimate the proportion of scholar children and adolescents with identified IgG and IgM antibodies against SARS-CoV-2. (2) Determine the proportion of asymptomatic or subclinical infections in SARS-CoV-2 positive individuals. (3) Explore social, demographic, economic, and clinical factors that may be potentially associated with seropositivity to SARS-CoV-2 in children and adolescents.",
"tested_antibody_classes": [
"IgG",
"IgA"
]
},
"study_numbers": {
"population": 1200000,
"study_population": 1000
},
"study_pi": {
"email": "serohub@helmholtz-hzi.de",
"institution": "Helmholtz (HZI) and Universidad Nacional de Colombia",
"name": "Gérard Krause and Fernando Pio De La Hoz Restrepo",
"role": "Professor"
},
"team": [
{
"email": "serohub@helmholtz-hzi.de",
"institution": "Helmholtz (HZI)",
"name": "Gérard Krause",
"position": "Head of Department Epidemiology",
"role": "Principal Investigator",
"title": "Prof. Dr. med."
},
{
"email": "fpdelahozr@unal.edu.co",
"institution": "Universidad Nacional de Colombia",
"name": "Fernando Pio De La Hoz Restrepo",
"position": "Director Public Health Department, Faculty of Medicine",
"role": "Principal investigator",
"title": "Prof. MD. PhD"
},
{
"email": "",
"institution": "Helmholtz (HZI)",
"name": "Tobias Kerrinnes",
"position": "",
"role": "Co-principal investigator",
"title": "Dr."
},
{
"email": "",
"institution": "Helmholtz (HZI)",
"name": "Monika Strengert",
"position": "Head of Laboratory",
"role": "Co-principal investigator",
"title": "PhD"
},
{
"email": "Johanna.Torres@helmholtz-hzi.de",
"institution": "Helmholtz (HZI) and Universidad Nacional de Colombia",
"name": "Johanna Carolina Torres Páez",
"position": "PhD Student",
"role": "Study Coordinator",
"title": "MD. MSc. Sp Pediatrics. "
},
{
"email": "",
"institution": "Helmholtz (HZI) and Universidad Nacional de Colombia",
"name": "Nathalie Verónica Fernández Villalobos",
"position": "PhD Student",
"role": "Study Coordinator",
"title": "MSc."
}
],
"title": "Seroepidemiologic study on SARS CoV2 infection in scholar children in Bogotá, Colombia "
}