Serial cross-sectional seroprevalence study of SARS-CoV-2 infection during and post-epidemic periods in Heidelberg and the Rhein-Neckar region, Germany

Brief Summary in Lay Language

The objective of this study is to determine the proportion of people in the general population of Heidelberg and the Rhein-Neckar region with antibodies against the coronavirus.

Brief Summary in Scientific Language

The primary objective of this study is to estimate the age-group specific prevalence of antibodies to SARS-CoV-2 among the general population of Heidelberg and the Rhein-Neckar region. In total 1500 persons from five age-groups will be randomly selected from the population registers. Study participants will be tested for antibodies at three different time points: one study visit will take place during the current epidemic, one post-epidemic and one between these two timepoints. A questionnaire will be administered at each study visit to collect information about symptoms and potential risk factors for SARS-CoV-2 infection.

More information here: link

Study Overview

Study nameSerial cross-sectional seroprevalence study of SARS-CoV-2 infection during and post-epidemic periods in Heidelberg and the Rhein-Neckar region, Germany
ProjectSARS-CoV-2 seroprevalence study
Sources of Monetary or Material SupportSAP (Systeme, Anwendungen, Produkte in der Datenverarbeitung)
Region(s)Germany
Location(s)Heidelberg and the Rhein-Neckar Kreis (16 municipalities in total)
Primary outcomeSeroprevalence for SARS-CoV-2, stratified by age over time
Research QuestionThe age-group specific prevalence of cross-reactive antibodies to SARS-CoV-2 among the general population of Heidelberg and the Rhein-Neckar region (RNR) in Germany
Diagnostic test(s) used
  • ELISA
  • Neutralization Assay
Antibody class(es)IgG, IgM
Study population N1500
Total population in the area~700,000
Primary outcomeSeroprevalence for SARS-CoV-2, stratified by age over time
Principal InvestigatorClaudia Denkinger , University Hospital Heidelberg, Division of Tropical Medicine , Claudia.Denkinger@uni-heidelberg.de
Team members
  • Claudia Denkinger, Principal Investigator, University Hospital Heidelberg, Division of Tropical Medicine
  • Ivonne Morales, Kerstin Rosenberger, Principal Investigator, University Hospital Heidelberg, Division of Tropical Medicine
Period2020-07 till 2020-10
Study start2020-05
First results expected2020-12

Study metadata

{
   "abbreviation": "SARS-CoV-2 seroprevalence study",
   "draft": false,
   "iscjklanguage": false,
   "lastmod": "2020-07-28T13:25:06+02:00",
   "logo_url": "/img/uploads/hd_trop.png",
   "project_url": null,
   "recruitment": {
     "country": [
       "Germany"
     ],
     "group": "General population",
     "location": [
       {
         "latitude": 49.4137373,
         "longitude": 8.6594131,
         "place_name": "Heidelberg and the Rhein-Neckar Kreis (16 municipalities in total)"
       }
     ],
     "type": "Random selection"
   },
   "results": {
     "doi_preprint": null
   },
   "study_dates": {
     "sample_end": "2020-10",
     "sample_start": "2020-07",
     "study_first_results": "2020-12",
     "study_start": "2020-05"
   },
   "study_info": {
     "diagnostic_test": [
       {
         "address": null,
         "antibody_classes": null,
         "company": null,
         "product": "ELISA"
       },
       {
         "address": null,
         "antibody_classes": null,
         "company": null,
         "product": "Neutralization Assay"
       }
     ],
     "funding_sources": "SAP (Systeme, Anwendungen, Produkte in der Datenverarbeitung)",
     "primary_outcomes": "Seroprevalence for SARS-CoV-2, stratified by age over time",
     "research_question": "The age-group specific prevalence of cross-reactive antibodies to SARS-CoV-2 among the general population of Heidelberg and the Rhein-Neckar region (RNR) in Germany",
     "tested_antibody_classes": [
       "IgG",
       "IgM"
     ]
   },
   "study_numbers": {
     "population": "~700,000",
     "study_population": 1500
   },
   "study_pi": {
     "email": "Claudia.Denkinger@uni-heidelberg.de",
     "institution": "University Hospital Heidelberg, Division of Tropical Medicine",
     "name": "Claudia Denkinger"
   },
   "team": [
     {
       "email": "Claudia.Denkinger@uni-heidelberg.de",
       "institution": "University Hospital Heidelberg, Division of Tropical Medicine",
       "name": "Claudia Denkinger",
       "position": "Section Director",
       "role": "Principal Investigator",
       "title": "Dr. med."
     },
     {
       "email": "ivonne.morales@uni-heidelberg.de, kerstin.rosenberger@uni-heidelberg.de",
       "institution": "University Hospital Heidelberg, Division of Tropical Medicine",
       "name": "Ivonne Morales, Kerstin Rosenberger",
       "position": "Epidemiologists",
       "role": "Principal Investigator",
       "title": "Dr. rer. nat., Dr. sc. hum."
     }
   ],
   "title": "Serial cross-sectional seroprevalence study of SARS-CoV-2 infection during and post-epidemic periods in Heidelberg and the Rhein-Neckar region, Germany"
 }