There is no reliable data on the actual prevalence of SARS-CoV-2 in the population. Representative studies would therefore be necessary. A representative population group could be all hospital employees, from cleaning staff to administrative staff to nurses and doctors. At least this would be a representative group of healthcare workers. All employees are included in this prospective observational study to demonstrate SARS-CoV-2 through repeated molecular tests and repeated antibody tests. For this purpose, a weekly smear for PCR on SARS-CoV-2 and weekly antibody tests are carried out. In addition, blood samples are preserved for testing for seroconversion. This data is correlated with a daily online survey. All data are evaluated every 3 months to determine the spread pattern.
Study is published in : International Journal of Infectious Diseases
Study Overview
| Study name | Prospective molecular biological and serological examination for the detection of SARS-CoV-2 (COVID-19) in employees of a hospital of regular care in Germany |
| Project | ProCoV |
| Sources of Monetary or Material Support | Institutional budget, no external funding (budget of sponsor/PI) |
| Region(s) | Germany |
| Location(s) | Reinbek |
| Primary outcome | How many employees develop a COVID-19 positive test and how many develop antibodies in the sense of a seroconversion? |
| Secondary outcome | [Correlation between symptoms and positive test results Do certain groups show certain symptoms and certain courses?] |
| Diagnostic test(s) used |
|
| Antibody class(es) | IgG |
| Study population N | 871 |
| Total population in the area | 1081 |
| Principal Investigator | Tim Strate , Hospital Reinbek , chirurgie@krankenhaus-reinbek.de |
| Team members |
|
| Period | 2020-04-14 till 2021-06-16 |
| Study start | 2020-03-25 |
| First results expected | 2021-01 |
Study metadata
{
"abbreviation": "ProCoV",
"draft": false,
"iscjklanguage": false,
"lastmod": "2021-03-12T10:35:44+01:00",
"recruitment": {
"country": [
"Germany"
],
"group": "Hospital employees",
"location": [
{
"latitude": 53.5103443,
"longitude": 10.2388103,
"place_name": "Reinbek"
}
],
"type": "monocenter study"
},
"study_dates": {
"sample_end": "2021-06-16",
"sample_start": "2020-04-14",
"study_first_results": "2021-01",
"study_start": "2020-03-25"
},
"study_info": {
"diagnostic_test": [
{
"address": "Lübeck, Germany",
"antibody_classes": [
"IgG"
],
"company": "EUROIMMUN",
"product": "multiple SARS-CoV-2 ELISA kits"
},
{
"address": "Chicago, USA",
"antibody_classes": [
"IgG"
],
"company": "Abbott",
"product": "SARS-CoV-2 IgG CMIA kit"
}
],
"funding_sources": "Institutional budget, no external funding (budget of sponsor/PI)",
"primary_outcomes": "How many employees develop a COVID-19 positive test and how many develop antibodies in the sense of a seroconversion?",
"secondary_outcomes": [
"Correlation between symptoms and positive test results",
"Do certain groups show certain symptoms and certain courses?"
],
"tested_antibody_classes": [
"IgG"
]
},
"study_numbers": {
"population": 1081,
"study_population": 871
},
"study_pi": {
"email": "chirurgie@krankenhaus-reinbek.de",
"institution": "Hospital Reinbek",
"name": "Tim Strate",
"role": "Professor"
},
"team": [
{
"institution": "Hospital Reinbek",
"name": "Tim Strate",
"position": "Head of Surgery Department",
"role": "Principal Investigator",
"title": "Prof. Dr. med."
},
{
"institution": "Hospital Reinbek",
"name": "Jonas Herzberg",
"position": "Assistant physician",
"role": "Study coordinator",
"title": "Dr. med."
}
],
"title": "Prospective molecular biological and serological examination for the detection of SARS-CoV-2 (COVID-19) in employees of a hospital of regular care in Germany"
}