Anti-SARS-CoV-2 IgG antibodies are associated with reduced viral load


Andrew Bryan, Susan L Fink, Meghan A Gattuso, Gregory Pepper, Anu Chaudhary, Mark Wener, Chihiro Morishima, Keith Jerome, Patrick C Mathias, Alexander L Greninger

Anti-SARS-CoV-2 antibodies have been described, but correlation with virologic outcomes is limited. Here, we find anti-SARS-CoV-2 IgG to be associated with reduced viral load. High viral loads were rare in individuals who had seroconverted. Higher viral load on admission was associated with increased 30-day mortality (OR 4.20 [95% CI: 1.62-10.86]).

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